Status:
RECRUITING
The NACHO Trial (Nut Allergy Children OIT)
Lead Sponsor:
HUS Skin and Allergy Hospital
Conditions:
Oral Immunotherapy for Food Allergy
Tree Nut Allergy
Eligibility:
All Genders
1-17 years
Phase:
NA
Brief Summary
Most food allergies that begin in early childhood are mild and resolve by school age, but nut allergies persist in about 80-90% of individuals into adulthood. The consumption of nuts, particularly cas...
Eligibility Criteria
Inclusion
- Age 6 months - 17 years
- Sensitization to cashew nut (allergen-specific IgE or positive skin PRICK test)
- Positive oral food challenge for cashew nut
Exclusion
- Poor adherence
- Uncontrolled or severe asthma
- Uncontrolled active or severe or atopic dermatitis
- Chronic urticaria
- Eosinophilic esophagitis or other gastrointestinal eosinophilic disorders
- Active malignant neoplasia
- Active systemic, autoimmune disease
- Diabetes treated with insulin
- Severe systemic illness or severe medical conditions such as cardiovascular or lung diseases
- Medication with beta blockers
- Medication with ACE-inhibitors
- Mastocytosis
- Pregnancy or breastfeeding
- Language barriers (not fluent Finnish or Swedish)
Key Trial Info
Start Date :
September 13 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 5 2029
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT06930950
Start Date
September 13 2024
End Date
November 5 2029
Last Update
April 16 2025
Active Locations (1)
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1
HUS Skin and Allergy Hospital
Helsinki, Finland