Status:
ENROLLING_BY_INVITATION
The Efficacy and Safety of Transcranial Temporal Interference Stimulation (tTIS) Targeting the Right Globus Pallidus Internus (GPi) for Motor Symptoms in Patients With PD
Lead Sponsor:
Yanghua Tian
Conditions:
Temporal Interference Stimulation
Parkinson's Disease
Eligibility:
All Genders
50-80 years
Phase:
NA
Brief Summary
To demonstrate that intervention targeting the right globus pallidus internus (GPi) using transcranial temporal interference stimulation can improve motor symptoms in patients with Parkinson's disease...
Detailed Description
Each of patients received either 30-minute or sham tTIS of the right GPi. Before and immediately after the stimulation, participants completed the Movement Disorder Society-Unified Parkinson's Disease...
Eligibility Criteria
Inclusion
- Meeting the diagnostic criteria for Parkinson's disease in China (2016 version), diagnosed as PD by two neurologists;
- Hoehn-Yahr stage 1.5-4;
- Age \> 50 years old;
- No signs of moderate to severe depression: Beck Depression Inventory-II (BDI-II) score \< 20;
- No signs of dementia: Mini-Mental State Examination (MMSE) score \> 21;
- No change in medication regimen in the four weeks prior to enrollment;
- Right-handed.
Exclusion
- History of other neuropsychiatric disorders;
- History of alcohol or drug abuse;
- Previous history of TMS or traditional TES treatment;
- Presence of non-MRI compatible metal implants in the body, such as deep brain stimulation devices, pacemakers or stents.
Key Trial Info
Start Date :
September 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06931483
Start Date
September 1 2024
End Date
December 31 2025
Last Update
April 17 2025
Active Locations (1)
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1
Anhui Medical University
Hefei, Anhui, China