Status:
RECRUITING
Remote Ischemic Conditioning for Acute Moderate Posterior Ischemic Stroke
Lead Sponsor:
General Hospital of Shenyang Military Region
Conditions:
Ischemic Stroke
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
A substantial body of basic and clinical research has demonstrated the protective effects of remote ischemic conditioning (RIC) in ischemic stroke. While these clinical studies support the safety of R...
Eligibility Criteria
Inclusion
- Age ≥18 years;
- Time from onset to treatment: ≤48 hours;
- Posterior circulation ischemic stroke confirmed by CT or MRI, including patients who have received intravenous thrombolysis or endovascular therapy;
- NIHSS score at randomization: 6-16, with an item 1a (level of consciousness) score of 0-1;
- First-ever stroke or prior stroke without significant residual disability (modified Rankin Scale score ≤1);
- Signed informed consent.
Exclusion
- intracerebral hemorrhage or subarachnoid hemorrhage；
- Uncontrolled severe hypertension (systolic blood pressure \>180 mmHg or diastolic blood pressure \>110 mmHg despite antihypertensive therapy)；
- Subclavian artery stenosis ≥ 50% or subclavian steal syndrome;
- Intracranial tumor, arteriovenous malformation or aneurysm;
- Severe abnormalities in coagulation;
- Any contraindication for remote ischemic adaptation: the upper limb has serious soft tissue injury, fracture or vascular injury, distal upper limb perivascular lesions, etc.;
- Participating in other clinical trials within 3 months;
- Comorbidity with any serious diseases and life expectancy is less than half a year;
- Patients not suitable for this clinical studies considered by researcher;
Key Trial Info
Start Date :
April 13 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2026
Estimated Enrollment :
960 Patients enrolled
Trial Details
Trial ID
NCT06931535
Start Date
April 13 2025
End Date
December 30 2026
Last Update
April 25 2025
Active Locations (1)
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1
Department of Neurology, General Hospital of Northern Theater Command
Shenyang, China, 110016