Status:
COMPLETED
Feasibility of an Augmented Two-Day Step Test and Causal Modeling for Post-Exertional Symptom Exacerbation in Post Covid-19 Syndrome
Lead Sponsor:
Universitair Ziekenhuis Brussel
Collaborating Sponsors:
Vrije Universiteit Brussel, Jette, Belgium
Conditions:
Long COVID
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study aims to evaluate exercise capacity and identify causes of Post-Exertional Symptom Exacerbation (PESE) in individuals with Long COVID. The investigators will compare the effectiveness of the...
Eligibility Criteria
Inclusion
- ≥18 years old
- Long COVID patients following the World Health Organization (WHO) criteria: "the continuation or development of new symptoms 3 months after the initial SARS-CoV-2 infection, with these symptoms lasting for at least 2 months with no other explanation"
- Previously active as described in the WHO recommendations for physical activity (minimal 150 minutes/week of moderate intensity aerobic physical activity OR minimal 75 minutes of vigorous intensity activity/week OR an equivalent combination of moderate- and vigorous-intensity activity throughout the week)
- Patient suffers from PESE as defined by the DePaul Symptom Questionnaire PEM (Post-Exertional Malaise) subscale
- Able to understand and sign written informed consent in Dutch, French or English
Exclusion
- Any pre-existing conditions or new medical diagnosis that can alternatively explain the current symptoms
- Being unable to perform a cycle ergometer test as decided upon by the medical study team members
- Suffering from Chronic Obstructive Pulmonary Disease (COPD) GOLD classification category 2,3 or 4 (by the Global Initiative for Chronic Obstructive Lung Disease)
- Allergies to medical adhesive bandages
- Skin conditions aggravated by sunlight including Porphyria
- Participation in other interventional trials
- Mitochondrial diseases
- Pregnancy
- Lactation
Key Trial Info
Start Date :
March 20 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 3 2025
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT06933017
Start Date
March 20 2025
End Date
July 3 2025
Last Update
July 8 2025
Active Locations (2)
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1
Universitair Ziekenhuis Brussel
Jette, Brussels Capital, Belgium, 1090
2
Universitair Ziekenhuis Brussel
Brussels, Jette, Belgium, 1090