Status:
RECRUITING
Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis
Lead Sponsor:
University Hospital Ostrava
Collaborating Sponsors:
University Hospital Olomouc
Masaryk Memorial Cancer Institute
Conditions:
Brain Metastases
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This multicentre proof-of-concept study, involving 4 centers, aims to establish the value of fractionated neoadjuvant stereotactic radiotherapy (NaSRT) as a new treatment paradigm for brain metastases...
Detailed Description
The prospective study will evaluate the efficacy and toxicity of neoadjuvant stereotactic radiotherapy (NaSRT) in patients with brain metastases (BM). Clinical data gathered will include local control...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Karnofsky Performance Status ≥ 60
- Histologically verified primary cancer disease
- MRI findings indicating BM
- Target BM indicated for surgical resection and any other metastases suitable for radical SRT.
- Target BM between 1 cm and 7 cm at the longest diameter on T1 post-contrast MR imaging
Exclusion
- Confirmed hematological malignity
- Small-cell (lung) carcinoma
- Peracute condition requiring immediate neurosurgical intervention
- History of whole-brain radiotherapy (WBRT)
- History of stereotactic radiotherapy to a target brain metastasis
- Pregnancy
- Inability to perform surgical resection of the target BM within 7 days after NaSRT
Key Trial Info
Start Date :
May 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2028
Estimated Enrollment :
260 Patients enrolled
Trial Details
Trial ID
NCT06933199
Start Date
May 1 2025
End Date
December 31 2028
Last Update
May 4 2025
Active Locations (4)
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1
University Hospital Ostrava
Ostrava, Moravian-Silesian Region, Czechia, 70852
2
Masaryk Memorial Cancer Institute
Brno, Czechia, 65653
3
University Hospital Hradec Králové
Hradec Králové, Czechia, 50005
4
University Hospital Olomouc
Olomouc, Czechia, 77900