Status:
COMPLETED
Evaluation of the Potential Effects of LRP5 and Tph1 in the Pathogenesis of Periodontal Disease Individuals With Stage III Grade B Periodontitis
Lead Sponsor:
Ankara University
Collaborating Sponsors:
The Scientific and Technological Research Council of Turkey
Conditions:
Periodontal Disease
Periodontitis (Stage 3)
Eligibility:
All Genders
18-70 years
Brief Summary
Objectives: The aim of this study was to determine the changes in LRP5 and TPH1 levels in serum and saliva samples due to periodontal inflammation and to evaluate the relationship between these values...
Eligibility Criteria
Inclusion
- \>18 years old,
- At least 16 permanent teeth except 3rd molars,
- Individuals who do not use orthodontic appliances,
- Individuals who are not pregnant or lactating,
- Individuals without any systemic disease that may affect periodontal health,
- Systemically healthy individuals,
- Individuals who have not used anti-inflammatory and/or anti-microbial drugs in the last 6 months,
- Individuals who have not received periodontal treatment in the last 1 year
Exclusion
- Pregnant/lactating individuals,
- Individuals who have used anti-inflammatory and/or anti-microbial drugs in the last 6 months,
- Individuals who have undergone periodontal treatment in the last 1 year,
- Individuals with psychiatric illness,
- Individuals with any oral infection,
- Individuals with \<16 teeth, excluding molars,
- Individuals with alcohol dependence,
- Individuals with active infectious disease (acute hepatitis, AIDS, tuberculosis), cancer or any systemic condition that may affect periodontal tissues,
- Individuals receiving treatment with drugs known to affect periodontal tissues (phenytoin, cyclosporine A, calcium channel blockers)
Key Trial Info
Start Date :
April 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 25 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06933797
Start Date
April 1 2024
End Date
February 25 2025
Last Update
April 18 2025
Active Locations (1)
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1
Ankara University, Faculty of Dentistry,
Ankara, Yenimahalle, Turkey (Türkiye), 06500