Status:
COMPLETED
Comparison of IL-8, FGF-1 and VEGF Levels in Pulpal Tissue, GCF and Dentinal Fluid Samples of Healthy, Reversible and Irreversible Pulpitis Diagnosed Teeth
Lead Sponsor:
Kırıkkale University
Conditions:
Pulpitis
Pulp Inflammation
Eligibility:
All Genders
16-60 years
Brief Summary
This study will include 51 patients diagnosed with healthy, reversible and irreversible pulpitis. IL-8, FGF-1 and VEGF levels will be compared using pulpal tissue, gingival crevicular fluid, dentinal ...
Eligibility Criteria
Inclusion
- Control group:
- Unrestored, caries-free vital teeth with healthy pulp
- Orthodontically indicated teeth for extraction
- wisdom teeth indicated for extraction in terms of oral hygiene
- teeth that require root canal treatment for prosthetic purposes
- Reversible pulpitis group:
- Teeth that react mildly to cold, hot, sour or sweet stimuli
- Teeth with no history of spontaneous pain
- Teeth that respond to cold test and electric pulp test within normal limits
- Teeth that are not sensitive to chewing or percussion
- Irreversible pulpitis group:
- Teeth with a history of continuous moderate or severe spontaneous pain
- Teeth sensitive to percussion
- Teeth without periapical pathology
Exclusion
- Patients requiring antibiotic prophylaxis.
- Patients with diabetes or haematological diseases.
- Patients who have used antibiotics or anti-inflammatory drugs in the last three weeks.
- Patients who are pregnant during treatment.
- Patients with intense plaque and tartar on their teeth, redness and bleeding in the gums.
- Patients with severe gingivitis, generalised periodontitis or periodontal pocket depth of more than 3 mm.
- Patients with no response to pulp sensitivity tests, presence of sinus tract, presence of periapical pathology on radiography.
- Teeth without pulp exposure after caries removal
Key Trial Info
Start Date :
March 3 2025
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 3 2025
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT06936553
Start Date
March 3 2025
End Date
October 3 2025
Last Update
December 5 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Kırıkkale University Faculty of Dentistry
Kırıkkale, Turkey (Türkiye), 71450