Status:
RECRUITING
EIT-Guided Ventilator Settings in AHRF
Lead Sponsor:
Mahidol University
Conditions:
Acute Hypoxemic Respiratory Failure
Acute Respiratory Distress Syndrome (ARDS)
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This exploratory study aims to investigate the effect of Electrical Impedance Tomography (EIT)-guided ventilator settings on mechanical power in patients with acute hypoxemic respiratory failure (AHRF...
Detailed Description
This exploratory study investigates the effect of Electrical Impedance Tomography (EIT)-guided PEEP titration on mechanical power in patients with acute hypoxemic respiratory failure (AHRF), including...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Diagnosed with acute hypoxemic respiratory failure within 48 hours
- Expected to require invasive mechanical ventilation ≥ 48 hours
- On mechanical ventilation within 24 hours
- Deep sedation and neuromuscular blockade
Exclusion
- Pregnancy
- Body mass index (BMI) \> 40 kg/m2
- Contraindications to using electrical impedance tomography, including
- Presence of a pacemaker or automatic implantable cardioverter-defibrillator (AICD)
- Inability to place the belt due to presence of surgical wounds dressing, thoracic or spinal cord trauma, recent thoracic surgery, etc.
- High risk for PEEP titration
- Hemodynamic instability defined as mean arterial pressure \< 65 mmHg despite optimization of fluid status and/or use of vasopressors
- Unstable cardiac arrhythmias
- Presence of lung bullae greater than 2 cm in diameter, identified on chest X-ray
- Presence of pneumothorax or pneumomediastinum
- Right-sided heart failure or severe pulmonary hypertension
- Neurologic conditions associated with a risk of intracranial hypertension
- Use of extracorporeal membrane oxygenation (ECMO)
- Severe chronic respiratory disease, defined as follows: requiring home oxygen therapy, or previous lung function showing (FEV1 less than 20 ml/kg PBW, or FEV1/FVC less than 50% predicted value), or chronic hypercapnia (PaCO2 greater than 45 mmHg) and/or chronic hypoxemia (PaO2 less than 55 mmHg) on FIO2 = 0.21, or radiographic x-ray evidence of any chronic over-inflation or chronic interstitial infiltration, or chronic restrictive, obstructive, neuromuscular, chest wall or pulmonary vascular disease resulting in severe exercise restriction (unable to climb stairs or perform household duties, secondary polycythemia, severe pulmonary hypertension with mean pulmonary arterial pressure greater than 40 mmHg)
- Decision to withhold life-sustaining treatment or palliative care.
- Moribund status with an expected survival of less than 24 hours.
- Refusal to provide informed consent
Key Trial Info
Start Date :
December 17 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT06936618
Start Date
December 17 2024
End Date
December 1 2026
Last Update
April 27 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Siriraj Hospital, Mahidol University
Bangkok, Thailand, 10700