Status:
RECRUITING
Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain Management
Lead Sponsor:
Ataturk University
Conditions:
Postoperative Pain
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
This study aims to evaluate the influence of genetic polymorphisms on the effectiveness of preoperative non-steroidal anti-inflammatory drugs (NSAIDs) in managing postoperative pain following endodont...
Eligibility Criteria
Inclusion
- Patients aged between 18 and 65 years
- Vital mandibular molar teeth diagnosed with symptomatic apical periodontitis
- ASA physical status classification I or II
- Preoperative VAS pain score greater than 50
- No known genetic disorders (e.g., Down syndrome, congenital insensitivity to pain)
Exclusion
- Patients classified as ASA III or higher
- Pregnant women or those suspected of being pregnant
- Presence of root canal curvature greater than 25° (Schilder classification)
- Patients with generalized periodontitis
- Presence of periodontal pockets deeper than 3 mm in the affected tooth
- History of systemic disease or known allergies
- Patients with diagnosed psychiatric or psychological disorders
- Presence of swelling, sinus tract, or preoperative tenderness on palpation
- Patients with bruxism
- Presence of resorption in the affected tooth
- Use of analgesic or anti-inflammatory drugs within 12 hours prior to the procedure
- Teeth with root fractures, ankylosis, or pathological mobility
Key Trial Info
Start Date :
May 10 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 3 2025
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06937853
Start Date
May 10 2024
End Date
August 3 2025
Last Update
July 11 2025
Active Locations (1)
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1
Ataturk University, Faculty of Dentistry, Department of Endodontics
Erzurum, Erzurum, Turkey (Türkiye), 25100