Status:
RECRUITING
Effects of Age, Sex and Isometric Exercise on Ventricular-Vascular Interactions During Cardiac Unloading
Lead Sponsor:
Tracy Baynard
Conditions:
Orthostatic Intolerance
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
As people get older, especially women, they often feel dizzy or even faint when they go from sitting or lying down to standing up. This happens because their blood pressure (BP) drops, which can lead ...
Detailed Description
Orthostatic intolerance becomes prevalent with advancing age (≤5% below age 50 but \~20% above age 70), and females are 3 to 5% more susceptible. Orthostatic intolerance is associated with syncope, fa...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- People aged 18-35 years or aged ≥ 65 years
- Healthy without symptons of orthostatic intolerance (i.e., nausea, sweating, weakness, visual disturbance)
- Seated systolic and/or diastolic BP \<140/90 mmHg;
- Body mass index \<35 kg/m2
- Recreationally active (≤ 2 days of structured physical activity)
- Regular menstrual cycles in young females
- Exclusion Criteria:
- People diagnosed with cardiovascular, diabetes, inflammatory or renal diseases and neurodegenerative-related dementia
- Tobacco users
- People prescribed with beta-blockers
- Pregnant females
- People unable to fit or get into the lower body negative pressure chamber
Exclusion
Key Trial Info
Start Date :
May 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 15 2026
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT06939153
Start Date
May 1 2025
End Date
January 15 2026
Last Update
August 22 2025
Active Locations (1)
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1
University of Massachusetts Boston
Boston, Massachusetts, United States, 02125