Status:
ACTIVE_NOT_RECRUITING
A Research Study of VCT220 in Adult Chinese Participants With Obesity
Lead Sponsor:
Vincentage Pharma Co., Ltd
Conditions:
Obesity
Overweight
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
The main purpose of this study is to assess how VCT220 tablets affect the bodyweight in obese or overweight adult participants. Participant will be randomly assigned to the high-dose group, low-dose g...
Eligibility Criteria
Inclusion
- Age 18-75 years, both male and female;
- At screening, BMI ≥ 28 kg/m² or 24 kg/m² ≤ BMI \< 28 kg/m² with at least one of the following conditions:
- Comorbid prediabetes (impaired fasting glucose and/or abnormal glucose tolerance), hypertension, dyslipidemia, or fatty liver (within the past 6 months prior to screening);
- Comorbid weight-bearing joint pain (as determined by the investigator, excluding joint pain caused by other diseases);
- Obesity-related shortness of breath or obstructive sleep apnea syndrome;
- Weight change during the past 3 months due to diet and exercise control should not exceed 5% (self-reported); weight change calculation formula: (highest weight - lowest weight in the past 3 months) / highest weight \* 100%;
- Willing and able to maintain a stable diet and exercise regimen throughout the study;
- Fully understands the purpose of the study, able to communicate well with the investigator, can comprehend and comply with the requirements of this study, and is willing to sign the informed consent form
Exclusion
- Patients with type 1, type 2, or other types of diabetes.
- A history of endocrine diseases or obesity caused by single gene mutations, including but not limited to hypothalamic obesity, pituitary obesity, hypothyroid obesity, Cushing's syndrome, insulinoma, acromegaly, and hypogonadism.
- A history of weight-loss surgery (except for liposuction performed more than 1 year ago) or plans to undergo weight-loss surgery, use weight-loss devices, or medical equipment during the study.
- Has used any of the following medications or treatments:
- Has previously used any GLP-1 receptor agonists (GLP-1RAs), GLP-1-related multi-target agonists (such as GLP-1/glucose-dependent insulinotropic peptide \[GIP\] dual receptor agonists, GLP-1 receptor/glucagon receptor \[GCGR\] dual agonists, GLP-1/GIP/glucagon \[GCG\] triple receptor agonists, etc.), or combination formulations containing GLP-1RAs (such as exenatide, liraglutide, semaglutide, benaglutide, etc.);
- Within the past 6 months prior to screening, has used any approved or unapproved weight-loss medications other than GLP-1 receptor agonists (GLP-1RAs) and GLP-1-related multi-target agonists (such as orlistat, phentermine/topiramate, naltrexone/bupropion, etc.), or weight-affecting herbal medicines, supplements, meal replacements, etc.;
- Within the past 3 months prior to screening, has used any antidiabetic medications, such as metformin, α-glucosidase inhibitors, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-glucose co-transporter-2 (SGLT-2) inhibitors, thiazolidinediones (TZDs), etc.;
- Within the past 3 months prior to screening, has used any medications that may cause significant weight gain, including systemic corticosteroid treatment for more than 1 week, tricyclic antidepressants, antipsychotic or anticonvulsant medications (e.g., imipramine, amitriptyline, mirtazapine, paroxetine, phenelzine, chlorpromazine, clozapine, olanzapine, valproic acid and its derivatives, lithium salts, methyldopa, etc.).
Key Trial Info
Start Date :
December 24 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 27 2026
Estimated Enrollment :
840 Patients enrolled
Trial Details
Trial ID
NCT06939296
Start Date
December 24 2024
End Date
March 27 2026
Last Update
April 22 2025
Active Locations (1)
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1
Peking University People's Hospital （ There are multiple sites in this clinical trial）
Beijing, Beijing Municipality, China