Status:
RECRUITING
Delayed Against Rapid Sequence Induction in Adults With Medical Diseases Undergoing Emergency Endotracheal Intubation.
Lead Sponsor:
Leipzig University Medical Center
Conditions:
Intubation in Intensive Care Units
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this clinical trial is to learn if it is feaseble to conduct a superiority trial comparing two methods for endotracheal intubation in critically ill patients. It will also learn about vali...
Eligibility Criteria
Inclusion
- Adult patients 18 years or older in need of emergency endotracheal intubation in the following 60 minutes.
- The planned operateur routinely performs endotracheal intubation in critically ill patients.
Exclusion
- Endotracheal Intubation performed during cardiopulmonary resuscitation or during "unstable ROSC", defined as Norepinephrine or Epinephrine dose \> 0,5 µg/kgKG/min after return of spontaneous circulation.
- Participation in the study is not warranted because of increased risk for the patient or otherwise not justifiable (e.g. active oral bleeding).
- Known allergy against Ketamine, Esketamine, Midazolam or Rocuronium.
- Known contraindication against Ketamine, Esketamine Midazolam or Rocuronium.
- Known or anticipated difficult airway with indication for awake fiberoptic intubation.
- Women with known pregnancy or breastfeeding.
Key Trial Info
Start Date :
June 27 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2027
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06940219
Start Date
June 27 2025
End Date
November 1 2027
Last Update
July 4 2025
Active Locations (1)
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1
Interdisciplinary Medical ICU, Leipzig Medical University Center
Leipzig, Saxony, Germany, 04317