Status:
RECRUITING
Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
Lead Sponsor:
University of Rochester
Collaborating Sponsors:
Patient-Centered Outcomes Research Institute
Conditions:
Sickle Cell Disease (SCD)
Eligibility:
All Genders
3-20 years
Brief Summary
The WeDecide study is a large observational study comparing the long-term effects of matched related donor hematopoietic stem cell transplantation (MRD HCT) and non-transplant disease-modifying therap...
Detailed Description
The WeDecide study is a large observational study comparing the long-term effects of two treatment options for pediatric patients with sickle cell disease (SCD): matched related donor hematopoietic st...
Eligibility Criteria
Inclusion
- Pediatric patients aged between 3 and 20.9 years.
- Children diagnosed with sickle cell Anemia (HB SS or HBSB0 Thalassemia)
- For the MRD HCT group, children who are candidates for matched related donor hematopoietic stem cell transplantation (MRD HCT).
- For the NT-DMT group, children who are receiving non-transplant disease-modifying therapies (NT-DMT) for SCD.
- Participants (or their guardians) must provide informed consent to be part of the study.
- Participants must be willing to undergo the necessary assessments and follow-up visits over the 3-year study period.
Exclusion
- Children younger than 3 years or older than 20.9 years.
- Children who do not have sickle cell anemia or related conditions.
- For the MRD HCT group, children who are not eligible for the transplant or do not have a matched related donor.
- Children who are currently enrolled in other clinical trials that might interfere with the WeDecide study.
- Children who are unable to adhere to the study protocol or follow-up requirements.
Key Trial Info
Start Date :
June 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2030
Estimated Enrollment :
480 Patients enrolled
Trial Details
Trial ID
NCT06941389
Start Date
June 1 2024
End Date
October 1 2030
Last Update
June 19 2025
Active Locations (37)
Enter a location and click search to find clinical trials sorted by distance.
1
Children's of Alabama (MRD-HCT)
Birmingham, Alabama, United States, 35294
2
Children's of Alabama (NT-DMT)
Birmingham, Alabama, United States, 35294
3
Nemours Children's Hospital, Delaware (MRD-HCT)
Wilmington, Delaware, United States, 19803
4
Children's National Hospital (MRD-HCT)
Washington D.C., District of Columbia, United States, 20010