Status:
ENROLLING_BY_INVITATION
Elucidating Hepatic Metabolism in Non-alcoholic Fatty Liver Disease
Lead Sponsor:
Helsinki University Central Hospital
Conditions:
Non-alcoholic Fatty Liver Disease (NAFLD)
Eligibility:
All Genders
18-75 years
Brief Summary
The goal of this observational, cross-sectional, case-control clinical study is to investigate the metabolic adaptations underlying the progression of nonalcoholic fatty liver disease (NAFLD), and to ...
Detailed Description
In this study the investigators study the metabolic adaptations underlying the progression of nonalcoholic fatty liver disease (NAFLD), namely hepatic mitochondrial reductive stress, ureagenesis, de n...
Eligibility Criteria
Inclusion
- The following inclusion/ exclusion criteria will be employed:
- Participants must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent.
- Subject must be likely to be available to complete all protocol-required study visits or procedures, to the best of the subject's and investigator's knowledge.
- Participants must be aged between 18-75 years.
- Participants are not allowed to have alcohol consumption of 350 g/week or more in women and 420 g/week or more in men.
- Participants are not allowed to have history of liver disease other than NAFLD as judged by history and physical examination and standard laboratory tests.
- Participants are not allowed to have claustrophobia or metal implants to allow magnetic resonance studies.
- Participants are not allowed to be pregnant or lactating.
- No known or anticipated difficulties in cannulation of peripheral veins.
- No history or evidence of any other clinically significant disorder, condition or disease other than those outlined above that, in the opinion of the investigator may compromise the ability of the subject to give written informed consent, would pose a risk to subject safety, or interfere with the study evaluation, procedures or completion.
Exclusion
Key Trial Info
Start Date :
May 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2030
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06942312
Start Date
May 1 2025
End Date
December 31 2030
Last Update
April 24 2025
Active Locations (1)
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1
Helsinki Central University Hospital
Helsinki, Uusimaa, Finland