Status:
RECRUITING
Evaluation of the Antioxidant and Anti-Inflammatory Capacities of the 'Rosy Red Valencia' and 'Olinda Valencia' Sweet Orange Varieties in Healthy Subjects
Lead Sponsor:
University of California, Davis
Conditions:
Healthy
Eligibility:
All Genders
25-40 years
Phase:
NA
Brief Summary
This study aims to evaluate the antioxidant and anti-inflammatory effects of acute and chronic consumption of two sweet orange (Citrus sinensis) varieties-'Rosy Red Valencia', which is rich in caroten...
Detailed Description
The health benefits of orange consumption have been described; however, the specific bioactive compounds responsible for these effects, as well as the underlying mechanisms of action, are not fully un...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Healthy men and women
- Age Range: 25-40 years
- Body mass index (BMI) with values between 21 and 29.9 kg\^m2
- Willingness to accept randomization, undergo the testing and intervention procedures, and deliver blood and stool samples
- Willingness to refrain from consuming foods rich in lycopene, phytoene, and phytofluene and limit the intake of some polyphenol-rich foods
- Willingness to discontinue the use of antioxidant supplements (such as carotenoid, polyphenol supplements), prebiotics and/or probiotics
- Exclusion Criteria:
- Pregnancy/lactation
- History of cardiovascular diseases, diabetes, uncontrolled hypertension, heart failure, stroke, liver, gallbladder, kidney, thyroid disease, gastrointestinal, autoimmune disorder, or cancer.
- Psychiatric disease that interferes with the understanding and implementation of the intervention
- History of eating disorders (such as bulimia nervosa and anorexia nervosa) in the last 5 years
- Current smokers
- Vegan, vegetarian, or other special diets (e.g., keto, paleo)
- Use of antibiotics or laxatives in the previous month
- History of substance abuse or alcohol abuse
- involvement in a weight loss intervention program within the past month or weight change \> 10%
- Self-report of allergic reactions to study products or their phytochemicals.
Exclusion
Key Trial Info
Start Date :
April 17 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 30 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06944210
Start Date
April 17 2025
End Date
January 30 2026
Last Update
April 25 2025
Active Locations (1)
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1
Nutrition Department, Ragle Facility, University of California Davis
Davis, California, United States, 95616