Status:
RECRUITING
Oxalate and Citrate in Humans - Response to Citrate
Lead Sponsor:
University of Chicago
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Kidney Stone
Healthy
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This is a single-center study that aims to learn more about how two compounds found in food, oxalate and citrate, interact in the body and may influence a person's chances of forming kidney stones. Th...
Detailed Description
Administration of oral potassium citrate without oxalate is the next step in determining whether there is a transporter-mediated mechanism linking urinary oxalate and citrate excretion in humans. The ...
Eligibility Criteria
Inclusion
- Stone formers (SF):
- Age 18-70
- History of at least one calcium-based kidney stone
- Non-stone formers (NSF):
- Age 18-70
- No history of kidney stone
- 24-hour urine oxalate within laboratory normal range (\<50 mg/day)
Exclusion
- History of primarily uric acid, cysteine, or struvite stones
- History of severe acid-base abnormality, very low (less than 100 mg/day) or very high (greater than 1500 mg/day) urine citrate
- Any controls or stone former (SF) participants who cannot stop diuretic medication or alkali supplementation for the course of the study period
- Chronic kidney disease (glomerular filtration rate \<75 milliliters per minute per 1.73 square meters \[mL/min/1.73 m²\])
- Non-stone formers (NSF) and stone formers (SF) with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2027
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT06944223
Start Date
October 1 2025
End Date
June 1 2027
Last Update
December 16 2025
Active Locations (1)
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1
University of Chicago Medical Center
Chicago, Illinois, United States, 60637