Status:
RECRUITING
Vaping and Smoking Project in People With Schizophrenia
Lead Sponsor:
State University of New York at Buffalo
Collaborating Sponsors:
Roswell Park Cancer Institute
National Institute on Drug Abuse (NIDA)
Conditions:
Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)
Eligibility:
All Genders
21-50 years
Phase:
NA
Brief Summary
The proposed research will characterize withdrawal among people with schizophrenia who vape daily compared to people with schizophrenia who smoke combustible cigarettes daily, filling critical gaps in...
Detailed Description
Although withdrawal is considered a key feature of nicotine/tobacco addiction that contributes to difficulty quitting smoking and likely electronic nicotine delivery systems (ENDS; e.g., electronic ci...
Eligibility Criteria
Inclusion
- 6+ months of daily/near-daily nicotine vaping or cigarette smoking
- 200+ ng/mL cotinine on a commercially-available quick screen
- stable antipsychotic medication dose (no changes in past 6 months).
- Current
Exclusion
- intention to quit daily/near-daily vaping/smoking in the next month
- current (2+ days out of the past 7) use of pipe tobacco, hookah/shisha, smokeless tobacco, dissolvable tobacco, nicotine pouches. For vaping group only, current (2+ days out of past 7) use of cigars, cigarillos, or filtered cigars that are filled with tobacco or a mix of tobacco and marijuana
- current use of any smoking cessation medication
- current severe substance dependence other than tobacco/nicotine (including cannabis; NIDA Modified ASSIST of 27+)
- current (past 2 weeks) suicidal ideation with intent and/or plan
- pregnancy (intake urine screen)
- florid psychosis or severe cognitive symptoms (score of ≥5 on PANSS items delusions (P1), hallucinatory behavior (P3), or unusual thought content (G9), conceptual disorganization (P2), abstract thinking (N5), or poor attention (G11) or a score ≥6 on grandiosity (P5) or suspiciousness (P6)
Key Trial Info
Start Date :
February 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2027
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT06944847
Start Date
February 15 2025
End Date
April 1 2027
Last Update
April 25 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University at Buffalo
Buffalo, New York, United States, 14260