Status:
RECRUITING
Deciphering the Genetic Architecture of Autoimmune Diseases
Lead Sponsor:
National Human Genome Research Institute (NHGRI)
Conditions:
Autoimmune Diseases
Eligibility:
All Genders
18-115 years
Brief Summary
Background: Autoimmune diseases can be caused by genes people inherit from their parents. The gene changes that cause these diseases have been well studied in people with European and Asian ancestors...
Detailed Description
SUMMARY: The goal of this proposal is to investigate the genomic origins of heterogeneity in both risk and specific phenotype of autoimmune diseases, with a particular emphasis on understanding and a...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Any person who meets the criteria for inclusion in the study will be considered and must have the patient's signed informed consent for participation.
- Autoimmune Disease Diagnosis:
- Cases:
- Patients diagnosed with SLE, Sjogren's disease, scleroderma, rheumatoid arthritis, seronegative spondyloarthropathies, and systemic vasculitis, as defined by the American College of Rheumatology classification criteria.
- Over 18 years old
- Controls:
- Family members of identified cases, and unrelated individuals. The controls would be from the same community as the patients and families studied, and of the same age and gender. Screening for autoimmune diseases and allergic diseases will be performed.
- Over 18 years old
- EXCLUSION CRITERIA:
- People diagnosed with a chronic viral disease: HIV, hepatitis C or HTLV-1.
Exclusion
Key Trial Info
Start Date :
January 14 2026
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 22 2030
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT06948110
Start Date
January 14 2026
End Date
April 22 2030
Last Update
January 9 2026
Active Locations (2)
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1
National Human Genome Research Institute (NHGRI)
Bethesda, Maryland, United States, 20892
2
Amazon Rainforest
Lima, Peru