Status:
NOT_YET_RECRUITING
AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions
Lead Sponsor:
University of Alabama at Birmingham
Conditions:
Stroke, Chronic
Aging
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
The AMPLIFI study (Adaptive Modulation of Plasticity through Lactate and Fitness Interventions) investigates how short-term aerobic exercise influences brain plasticity and learning in older adults an...
Detailed Description
The AMPLIFI study is a mechanistic clinical trial designed to investigate the neurophysiological effects of acute aerobic exercise on cortical plasticity and motor learning in older adults and individ...
Eligibility Criteria
Inclusion
- For All Participants:
- Able to provide informed consent
- Right-handed (for TMS consistency)
- English-speaking
- Clearance for moderate-intensity aerobic exercise
- Able to safely sit and pedal a stationary cycle ergometer
- No contraindications to TMS (e.g., no metal in skull, pacemakers, or seizure history)
- Younger Adults (18-35):
- No history of neurological or psychiatric conditions
- Not currently on medications that affect the central nervous system
- Older Adults (60-85):
- No diagnosis of dementia
- Independent in activities of daily living
- No stroke history
- Stroke Survivors (18-85):
- At least 6 months post-stroke (chronic phase)
- Medically stable and cleared for aerobic exercise
- Able to engage in motor learning task (with or without hemiparetic adaptations)
Exclusion
- History of epilepsy or seizures
- Current substance abuse or uncontrolled psychiatric disorder
- Severe cardiovascular disease or unstable medical condition
- Pregnancy
- Contraindications to TMS or exercise testing (e.g., implanted neurostimulators, severe hypertension)
- Participation in another interventional trial within the past 30 days
Key Trial Info
Start Date :
February 14 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2030
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT06950060
Start Date
February 14 2026
End Date
January 1 2030
Last Update
January 9 2026
Active Locations (1)
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1
CH19 933 19th St S
Birmingham, Alabama, United States, 35233