Status:
NOT_YET_RECRUITING
Hemodynamic Effects of Ketone Esters in Patients With Sepsis Induced Cardiomyopathy
Lead Sponsor:
Tor Biering-Sørensen
Conditions:
Sepsis Induced Cardiomyopathy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and is associated with a high mortality rate in the ICU. Sepsis induced cardiomyopathy (SICM) is a mu...
Eligibility Criteria
Inclusion
- Patients ≥ 18 years of age admitted to the the intensive care unit (ICU)
- LVEF \< 40% determined by a screening echocardiography (two projections: apical 4 chamber and 2 chamber) and analysed according to the Simpson biplane method
- Ability for study personnel to perform transthoracic echocardiography
- Suspected or documented infection (suspected infection is defined as ongoing antibiotic treatment and/or body fluid culture sampling performed within 72 hours before screening)
Exclusion
- Diagnosis of heart failure with reduced ejection fraction prior to ICU admission according to health records
- Surgical cause of ICU admission
- For patients in shock: Other primary causes of shock than sepsis (i.e. hypovolemia, haemorrhage, cardiogenic etiology, pulmonary embolism, anaphylaxis)
- Blood pH \< 7.20
- Severe gastroparesis
- Inability to position a nasogastric tube
Key Trial Info
Start Date :
June 10 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2026
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT06952140
Start Date
June 10 2025
End Date
July 1 2026
Last Update
May 28 2025
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