Status:
ENROLLING_BY_INVITATION
At Home Ammonia Monitoring of Inborn Errors of Ammonia Metabolism
Lead Sponsor:
Sequitur Health Corp.
Collaborating Sponsors:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Oregon Health and Science University
Conditions:
Urea Cycle Disorders
Organic Acidemias
Eligibility:
All Genders
12+ years
Phase:
NA
Brief Summary
The goal of this observational study is to learn if people with certain ammonia metabolism disorders will measure their ammonia levels at home. The main question it aims to answer is: • Will partici...
Detailed Description
Ammonium (NH4+, ion in aqueous solution) exists in equilibrium with ammonia (NH3, gas) according to the equilibrium reaction: NH3+ + H+ ↔ NH4+, which has a pKa of 9.25.\[1\] Total ammonia is the sum o...
Eligibility Criteria
Inclusion
- Confirmed ammonia disorder such as
- Ornithine transcarbamylase deficiency
- Systemic primary carnitine deficiency
- Type I citrullinemia
- Argininosuccinic aciduria
- Isolated methylmalonic acidemia
- Type II citrullinemia
- Propionic acidemia
- Isovaleric acidemia
- Multiple acyl-CoA dehydrogenase deficiency
- Pyruvate carboxylase deficiency
- Argininemia (arginase deficiency)
- Carbamoyl phosphate synthase I deficiency
- Dihydrolipoamide dehydrogenase deficiency
- Lysinuric protein intolerance
- Hyperornithinemia-hyperammonemia-homocitrullinuria
- Carnitine-acylcarnitine translocase deficiency
- Carbonic anhydrase VA deficiency
- N-acetyl glutamate synthetase deficiency
- English Literacy
Exclusion
- Incarcerated
- Presence of a non-inborn error of metabolism medical condition associated with abnormal ammonia metabolism (e.g., end stage liver disease).
- Unable to read in English
Key Trial Info
Start Date :
September 23 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2027
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06953505
Start Date
September 23 2025
End Date
August 1 2027
Last Update
October 6 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Oregon Health & Science University
Portland, Oregon, United States, 97239-3098