Status:
RECRUITING
Study on the Optimal Combination Pattern of the Combined Treatment of Radiotherapy and Immunotherapy for the Abscopal Effect in Non-Small Cell Lung Cancer (NSCLC) With Multiple Metastases
Lead Sponsor:
Xinqiao Hospital of Chongqing
Conditions:
NSCLC Stage IV Without EGFR/ALK Mutation
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
Brief Summary
This study aims to conduct a prospective, multicenter, umbrella clinical study to compare the abscopal effects of different radiotherapy fractionation patterns combined with Benmelstobart, and to expl...
Eligibility Criteria
Inclusion
- Patient must meet all of the following inclusion criteria to be enrolled in this study:
- Non-small cell lung cancer confirmed by pathological histology.
- More than 3 metastatic lesions.
- No brain metastases or stable lesions.
- Negative for driver genes (including EGFR, ALK, ROS, BRAF, MET, RET).
- Performance status (PS) score of 0-1, with an expected survival period of more than 3 months.
- Age between 18 and 75 years old.
- Assessment by PET-CT (including FDG and FMISO, not mandatory).
- No contraindications to immunotherapy and radiotherapy.
- Signed the informed consent form.
Exclusion
- Patients with any of the following criteria are not eligible for enrollment in this study:
- Those with severe dysfunction of important vital organs (heart, liver, kidney).
- Those accompanied by other malignant tumors.
- Uncontrolled heart diseases or myocardial infarction within the past 6 months.
- Those with a history of mental illness.
- Other situations in which the researcher deems it inappropriate for the subject to participate in the study.
Key Trial Info
Start Date :
July 9 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
366 Patients enrolled
Trial Details
Trial ID
NCT06953843
Start Date
July 9 2025
End Date
December 31 2027
Last Update
July 14 2025
Active Locations (1)
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1
the second affiliated hospital of Army medical university
Chongqing, Chongqing Municipality, China, 400037