Status:
RECRUITING
Restricted Versus Liberal Fluid Intake for Prevention of Bronchopulmonary Dysplasia
Lead Sponsor:
University Children's Hospital Basel
Collaborating Sponsors:
Swiss Neonatal Network
Conditions:
Bronchopulmonary Dysplasia
Eligibility:
All Genders
8+ years
Phase:
NA
Brief Summary
The aim of this study is to determine whether restricted fluid intake (135 ±5 mL/kg/day) compared to liberal fluid intake (165 ±5 mL/kg/day) from day 8 of life reduces the incidence of bronchopulmonar...
Detailed Description
Complications of preterm birth remain the leading cause of death in children under five years of age worldwide, accounting for approximately one million deaths annually. Among the survivors, bronchopu...
Eligibility Criteria
Inclusion
- Hospitalised preterm infants born before 30 weeks 0 days gestation
- Signed informed consent for further research use of health-related data
Exclusion
- congenital malformations
- diseases likely to affect life expectancy, lung function, fluid strategy, or neurodevelopment
- renal disease requiring fluid management outside the clinical standard of care
- congenital heart disease not including patent ductus arteriosus (PDA)
Key Trial Info
Start Date :
July 12 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2029
Estimated Enrollment :
750 Patients enrolled
Trial Details
Trial ID
NCT06954142
Start Date
July 12 2025
End Date
December 1 2029
Last Update
August 19 2025
Active Locations (9)
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1
Kantonsspital Aarau AG, Klinik für Kinder u. Jugendliche
Aarau, Switzerland, 5001
2
University Children's Hospital Basel (UKBB)
Basel, Switzerland, 4056
3
Inselspital Bern, Kinderklinik
Bern, Switzerland, 3010
4
Kantonsspital Graubünden, Departement Kinder- und Jugendmedizin
Chur, Switzerland, 7000