Status:
RECRUITING
Prognostic Potential of Olfactory Function in Glioblastoma: a Prospective Observational Study
Lead Sponsor:
Sied Kebir
Collaborating Sponsors:
Münster University Hospital, Germany
Conditions:
Glioblastoma Multiforme, Adult
Glioblastoma or Gliosarcoma
Eligibility:
All Genders
18+ years
Brief Summary
The study aims to investigate the prognostic significance of olfactory function in patients with glioblastoma. We are examining olfactory function at various points during therapy and correlating the ...
Detailed Description
Background: Olfactory impairment is frequent in glioblastoma and is associated with poor overall survival. However, earlier studies were limited by confounding of important predictive factors and the ...
Eligibility Criteria
Inclusion
- At least 18 years of age
- Newly-diagnosed glioblastoma (IDH wild-type)
- Never received prior chemotherapy
- Never received radiotherapy to the head or neck before
- KPS ≥ 70
- No history of severe head or brain trauma requiring ICU admission or classified as Glasgow Coma Scale grade 3
- No respiratory infection at the time of inclusion
- No significant aphasia
Exclusion
- Presence of Neurodegenerative diseases (e.g. Parkinson's disease, Alzheimer's disease, Huntington's disease, Korsakoff's syndrome, Pick's disease, Shy-Drager syndrome)
- History of invasive tumors or surgery in the head or neck area, except for surgeries for non-invasive skin tumors (e.g. basal cell carcinomas)
- Permanent olfactory impairment following infections (e.g., influenza, coronavirus)
- Conditions that, in the examiner's judgment, could interfere with the participant's study compliance (e.g., schizophrenia)
- Language barriers likely to interfere with participation or comprehension of study procedures.
Key Trial Info
Start Date :
May 3 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2028
Estimated Enrollment :
128 Patients enrolled
Trial Details
Trial ID
NCT06954636
Start Date
May 3 2023
End Date
December 31 2028
Last Update
July 8 2025
Active Locations (2)
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1
University Hospital Essen, Department of Neurology, Division of Clinical Neuro-Oncology
Essen, Germany, 45147
2
Department of Neurosurgery
Münster, Germany