Status:
RECRUITING
Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course
Lead Sponsor:
United States Department of Defense
Collaborating Sponsors:
University of Minnesota
Lowcountry Center for Veterans Research
Conditions:
Post Traumatic Stress Disorder
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Investigators' overall objective is to compare methods of identifying individuals who may be experiencing challenges in Cognitive Processing Therapy (CPT) and compare methods of intervening to optimiz...
Detailed Description
Background: Trauma-focused treatments (TFTs) for PTSD, including Cognitive Processing Therapy (CPT), result in clinically significant symptom relief for many. However, they are not equally effective f...
Eligibility Criteria
Inclusion
- Veterans interested in outpatient VA psychotherapy for PTSD
- Meets DSM-5 criteria for PTSD
- Be able to provide informed consent
- Be willing to be randomized
- Agree to not receive non-study psychotherapy for PTSD during study treatment (case management, supportive therapy/group, and concurrent substance use treatment are allowable)
Exclusion
- Severe cognitive impairment
- Current suicidal or homicidal intent with a specific plan
- Uncontrolled psychotic or manic symptoms
- A psychiatric medication change in the past month
- A severe SUD as diagnosed by the DSM-5
Key Trial Info
Start Date :
March 17 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2028
Estimated Enrollment :
280 Patients enrolled
Trial Details
Trial ID
NCT06957067
Start Date
March 17 2025
End Date
August 31 2028
Last Update
November 14 2025
Active Locations (4)
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1
VA Phoenix Health Care System
Phoenix, Arizona, United States, 85012
2
New Orleans VA Medical Center
New Orleans, Louisiana, United States, 70119
3
Ralph H. Johnson VA Health Care System (Charleston VA)
Charleston, South Carolina, United States, 29401
4
VA Houston Healthcare System
Houston, Texas, United States, 77030