Status:
RECRUITING
Development and Validation of Microbiota and Metabolite-based Prediction Model for Recurrence of High-risk Colorectal Polyps After Polypectomy
Lead Sponsor:
Peking Union Medical College Hospital
Conditions:
Colorectal Polyp
Colorectal Cancer Recurrent
Eligibility:
All Genders
40-75 years
Brief Summary
The characteristics of the intestinal microbiota in high-risk colorectal polyp recurrence and their relationship with disease pathogenesis have not yet been fully elucidated. This study aims to analyz...
Eligibility Criteria
Inclusion
- patients aged 40-75 years who undergo the colonoscopy with at least 1 advanced premalignant polyps or ≥ 3 adenoma
Exclusion
- patient with severe physical diseases that prevented them from adhering to the examination requirements,
- patient with coagulopathy or other contraindications for biopsy or polypectomy,
- patient with previous surgical procedures on the gastrointestinal tract,
- presence of colorectal cancer or other malignant tumor at baseline
- presence of inflammatory bowel disease or hereditary polyposis syndromes (such as family adenomatous polyposis or Lynch syndrome)
- within 1 month before enrollment, oral antibiotics and probiotics were taken;
- inability to provide informed consent or refusal to participate in the study.
Key Trial Info
Start Date :
April 25 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 30 2026
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06957626
Start Date
April 25 2023
End Date
April 30 2026
Last Update
July 1 2025
Active Locations (1)
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1
Peking Union Medical College Hospital, 1 Shuaifuyuan, Dongcheng District, Beijing, China
Beijing, China, 100730