Status:
RECRUITING
Transcutaneous Auricular Vagus Nerve Stimulation and Quality of Recovery After Major Noncardiac Surgery
Lead Sponsor:
Peking University First Hospital
Conditions:
Vagus Nerve Stimulation
Transcutaneous Electric Nerve Stimulation
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel non-invasive neuromodulation technique. Existing evidence suggested that taVNS improves pain management, sleep quality, inflammatory...
Detailed Description
The evolution of quality improvement initiatives, such as Enhanced Recovery After Surgery (ERAS) protocols, has shifted perioperative management paradigms toward prioritizing patient-centered subjecti...
Eligibility Criteria
Inclusion
- Aged ≥18 years but \<85 years.
- Scheduled for elective or limited-time noncardiac surgery with expected duration ≥2 hours.
Exclusion
- Lesions or infections of the auricle skin.
- Recent or long-term use of cholinergic or anticholinergic medications.
- Neurosurgery.
- Expected mechanical ventilation with intubation for ≥1 day after surgery.
- Diagnosed schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis before surgery.
- Preoperative left ventricular ejection fraction (LVEF) \<30%, or those with sick sinus syndrome, sinus bradycardia (heart rate \<50 beats per minute), atrioventricular block of grade II or above, or implanted pacemaker.
- Inability to communicate due to coma, severe dementia, or language barrier before surgery, or unable to cooperate with intervention.
- American Society of Anesthesiologists physical status grade \>IV, or estimated survival \<24 hours.
Key Trial Info
Start Date :
May 13 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
320 Patients enrolled
Trial Details
Trial ID
NCT06957912
Start Date
May 13 2025
End Date
September 1 2026
Last Update
June 3 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034