Status:
RECRUITING
Neural Mechanism of Cerebrocardiac Syndrome Following Traumatic Brain Injury
Lead Sponsor:
Shanghai 6th People's Hospital
Conditions:
Traumatic Brain Injury
Cerebrocardiac Syndrome
Eligibility:
All Genders
18-80 years
Brief Summary
Cerebrocardiac syndrome (CCS), including myocardial injury, arrhythmia or heart failure is one of serious complications of traumatic brain injury (TBI), mostly occurs within seven days after TBI, whic...
Eligibility Criteria
Inclusion
- Patients with isolated closed head trauma
- Age 18-80 years old
- Admitted to hospital within 24 hours of injury
- Mild or moderate TBI (Glasgow Coma Scale score of 9-15)
- Signed consent form
Exclusion
- Severe TBI (Glasgow Coma Scale score of 3-8)
- A history of stroke, TBI, intracranial tumor or surgery in the past 1 year
- A history of coronary heart disease, structural heart disease and other primary heart diseases or suspected cardiac symptoms prior to injury
- Causes of abnormal cardiac biomarkers such as renal insufficiency, severe anemia, sepsis, cardiotoxic drugs and so on
- Not suitable for MRI examinations, such as pregnant women and those with metal implants in the body
- Undergo surgery prior to MRI examinations or cardiac testing
Key Trial Info
Start Date :
May 6 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 31 2027
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT06958406
Start Date
May 6 2025
End Date
July 31 2027
Last Update
May 6 2025
Active Locations (2)
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1
Shanghai 6th People's Hospital
Shanghai, China, 200233
2
Shanghai Sixth People's Hospital
Shanghai, China