Status:
COMPLETED
Chemotherapy-induced Lipid Profile Changes in Women With Early Breast Cancer
Lead Sponsor:
Cancer center Stefan Kukura Hospital Michalovce
Collaborating Sponsors:
Pavol Jozef Safarik University
Conditions:
Breast Neoplasms
Lipid Profile
Eligibility:
FEMALE
18-80 years
Brief Summary
Detection of changes in the lipid profile in early-stage breast cancer patients undergoing neoadjuvant or adjuvant chemotherapy with doxorubicin, cyclophosphamide, and paclitaxel.
Detailed Description
Despite the development of highly effective antitumor therapies over the past two decades (e.g., targeted therapy, immunotherapy), chemotherapy regimens including anthracyclines, taxanes, and cyclopho...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Female patients with newly diagnosed breast cancer, stage IB-IIIB, assigned to receive neoadjuvant or adjuvant chemotherapy.
- Histologically confirmed invasive adenocarcinoma of the breast, including hormone receptor-positive, HER2-positive (human epidermal growth factor receptor 2), or triple-negative breast cancer.
- Chemotherapy regimen based on doxorubicin, cyclophosphamide, and paclitaxel.
- Completion of all planned neoadjuvant or adjuvant chemotherapy cycles.
- Availability of complete lipid profile data at all required timepoints.
- Exclusion Criteria Prior breast cancer treatment (surgery, chemotherapy, radiotherapy, or systemic therapy).
- Ongoing or prior treatment with hypolipidemic (lipid-lowering) medications.
- Incomplete chemotherapy regimen (interrupted or prematurely terminated cycles).
- Presence of distant metastatic disease at diagnosis.
- Missing or incomplete lipid profile data.
Exclusion
Key Trial Info
Start Date :
March 5 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 28 2025
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT06958783
Start Date
March 5 2023
End Date
February 28 2025
Last Update
May 30 2025
Active Locations (1)
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1
Oncology Center, Štefan Kukura Hospital, Penta Hospitals, Michalovce
Michalovce, Slovakia, 07101