Status:
NOT_YET_RECRUITING
Evolution of Tissue Perfusion and Venous Congestion Markers in Fluid-Responsive Septic Shock Patients
Lead Sponsor:
Hospital Ambroise Paré Paris
Conditions:
Septic Shock
Fluid Resuscitation
Eligibility:
All Genders
Brief Summary
Septic shock remains a leading cause of mortality in intensive care, and while fluid resuscitation (FR) is a cornerstone of early management, its benefit-risk balance is highly variable. Excessive flu...
Detailed Description
Background and Rationale Sepsis and septic shock are among the leading causes of morbidity and mortality in intensive care units worldwide. Septic shock is defined as a subset of sepsis characterized ...
Eligibility Criteria
Inclusion
- Septic shock (sepsis-3 criteria)
- Under mechanical ventilation
- Central venous catheter in the superior vena cava territory and arterial catheter in place
- Response to fluid resuscitation as per standard definition (i.e., an increase in cardiac output \>10% assessed by subaortic velocity time integral \[VTI\] using echocardiography)
Exclusion
- Patient under 18 years of age
- Lack of social security coverage / adult under legal protection
- Pregnant woman
- Inability to obtain non-opposition consent
Key Trial Info
Start Date :
February 1 2026
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2027
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06958809
Start Date
February 1 2026
End Date
August 1 2027
Last Update
May 6 2025
Active Locations (1)
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1
Hôpital Ambroise Paré, Assistance Publique Hôpitaux de Paris,
Boulogne-Billancourt, France, 92100