Status:
ENROLLING_BY_INVITATION
Assessing Incretin Therapy for Cardiovascular Risk Reduction and Diabetes Remission( ITCRDR Study)
Lead Sponsor:
China-Japan Friendship Hospital
Conditions:
Diabetes Mellitus
Cardiovascular Diseases
Eligibility:
All Genders
30-70 years
Phase:
PHASE4
Brief Summary
This study used the diabetes prevention and follow-up research queue in Daqing and the public database of UKbiobank to evaluate the risk factors of cardiovascular and cerebrovascular events in diabete...
Eligibility Criteria
Inclusion
- Newly diagnosed diabetes, with no previous use of hypoglycemic medications or having discontinued such medications for more than 3 months.
- Blood glucose elevation detected within one year (fasting blood glucose exceeding 7 mmol/L, postprandial blood glucose or random blood glucose exceeding 11.1 mmol/L).
- Age between 30 and 70 years (inclusive of boundary values).
- Hemoglobin A1c between 7% and 10% (inclusive of boundary values).
- BMI between 24 and 32.5 kg/m² (inclusive of boundary values).
Exclusion
- History of coronary heart disease or cerebral infarction.
- Severe liver or kidney disease: alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \> 3 times the upper limit of normal (ULN); glomerular filtration rate less than 30 ml/min/1.73 m².
- History of malignant tumors.
- Use of systemic glucocorticoids (excluding local applications or inhalants) for one week or more within the three months prior to screening.
- Positive urine pregnancy test in women of childbearing age.
- History of pancreatitis, or amylase and/or lipase \> 3 times the ULN.
- Personal history or family history of medullary thyroid carcinoma (MTC) in first-degree relatives, or genetic predisposition to MTC (such as multiple endocrine neoplasia syndrome).
Key Trial Info
Start Date :
January 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
142 Patients enrolled
Trial Details
Trial ID
NCT06959784
Start Date
January 1 2024
End Date
December 31 2026
Last Update
May 7 2025
Active Locations (1)
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1
China-Japan Friendship hospital
Beijing, China, 100029