Status:
NOT_YET_RECRUITING
Effect of L-carnitine on Disease Activity in Patients With Mild to Moderate Knee Osteoarthritis
Lead Sponsor:
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
40+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to evaluate the effects of L-carnitine on symptomatic improvement, oxidative stress, and inflammation in mild to moderate knee osteoarthritis patients.
Detailed Description
Osteoarthritis (OA) is a progressive degenerative joint disease marked by cartilage degradation, synovial inflammation, and subchondral bone remodeling, resulting in persistent pain and disability. Th...
Eligibility Criteria
Inclusion
- Knee pain
- Radiographic evidence of mild to moderate knee osteoarthritis (Kellgren-Lawrence Grade: II-III)
- Above 40 years
- Both male and female
- hs-CRP ≥ 0.3mg/dl
Exclusion
- Renal impairment (S. creatinine \>1.5 mg/dl)
- Diagnosed with systemic inflammatory disorders, such as rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, gout
- Patients on immunosuppressant treatment
- Any history of intra-articular corticosteroid injections during the previous three months
- A history of knee surgery or trauma
- Any antioxidant vitamins use, such as A, C and E or history of use in the last two months
- History of taking L-carnitine and naproxen in last 2 months
- Pregnancy or lactation
- Participation in another clinical trial
Key Trial Info
Start Date :
May 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT06960694
Start Date
May 1 2025
End Date
January 1 2026
Last Update
May 7 2025
Active Locations (1)
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1
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Dhaka, Bangladesh, 1000