Status:
NOT_YET_RECRUITING
Mechanisms of Change in Behavioral Cough Suppression Therapy for Refractory Chronic Cough
Lead Sponsor:
University of Montana
Collaborating Sponsors:
University of Colorado, Denver
Emory University
Conditions:
Chronic Cough (CC)
Refractory Chronic Cough
Eligibility:
All Genders
18-99 years
Phase:
PHASE2
Brief Summary
This study is testing new ways to help people who have chronic cough that has not improved with typical treatments. One approach is called behavioral cough suppression (BCS) therapy, which teaches peo...
Detailed Description
Refractory chronic cough (RCC) is a persistent and costly condition that is difficult to treat, often persisting despite appropriate treatment of underlying causes. While behavioral cough suppression ...
Eligibility Criteria
Inclusion
- Diagnosis of refractory or unexplained chronic cough
- Normal chest x-ray within past 2 years, without change in cough symptoms
- If diagnosed with asthma, is it well controlled
- Normal spirometry (or FEV1/FVC of at least 70% if diagnosed with asthma) within two years, without change in symptoms since
- Laryngoscopy or stroboscopy within 2 years without evidence of structural pathology and no change in vocal quality since exam
- Proficient reader/speaker of English
- Willing to take a pregnancy test before enrollment (if applicable)
- Willing to use contraception during the study (if applicable)
- Demonstrates understanding in study procedures and risks in order to consent
Exclusion
- Currently a smoker of any substance
- Currently suffering from any signs of an upper respiratory infection (other than cough)
- Hemoptysis (coughing up blood)
- Pulmonary diagnosis other than asthma
- Used an ACE-inhibitor in the past 60 days
- Pregnant or trying to become pregnant
- Any complaints or clinical symptoms of dysphagia
- Live with or work with anyone with chronic cough
- The following additional exclusion criteria will apply to participants at University of Colorado:
- Presence of metal implants, devices or fragments in the body
- Claustrophobia
Key Trial Info
Start Date :
August 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2030
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06960759
Start Date
August 1 2025
End Date
March 31 2030
Last Update
May 11 2025
Active Locations (3)
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1
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045
2
Emory University
Atlanta, Georgia, United States, 30322
3
University of Montana
Missoula, Montana, United States, 59812