Status:
NOT_YET_RECRUITING
Ketamine and Dexmedetomidine for Delirium in Joint Arthroplasty
Lead Sponsor:
Istinye University
Conditions:
Postoperative Delirium
Postoperative Cognitive Dysfunction
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
This prospective, randomized, double-blind, placebo-controlled clinical trial aims to evaluate the effects of intraoperative ketamine and dexmedetomidine on the incidence of postoperative delirium (PO...
Eligibility Criteria
Inclusion
- Scheduled for elective total joint arthroplasty (hip or knee)
- ASA physical status I-III
- Age between 18 and 100 years
- Ability to provide informed consent and comply with cognitive assessments
Exclusion
- Pre-existing cognitive dysfunction or diagnosed neurodegenerative disease
- Hearing or language impairment interfering with MMSE/CAM evaluation
- Known allergy to ketamine or dexmedetomidine
- Significant cardiac arrhythmia (e.g., supraventricular tachycardia, 2nd or 3rd degree AV block)
- Renal insufficiency (GFR \<30 mL/min/1.73 m²)
- Severe hepatic dysfunction
Key Trial Info
Start Date :
May 5 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 15 2026
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06963294
Start Date
May 5 2026
End Date
July 15 2026
Last Update
May 9 2025
Active Locations (1)
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1
Istinye Üniversity
Istanbul, Merkez Mahallesi, Turkey (Türkiye), 34250