Status:
NOT_YET_RECRUITING
IL-40 and IL-41 Levels in Sepsis, Septic Shock, and Healthy Individuals
Lead Sponsor:
Melahat Yalcin Solak
Conditions:
Sepsis
Septic Shock
Eligibility:
All Genders
18+ years
Brief Summary
This study aims to investigate the blood levels of two recently identified immune-related proteins, Interleukin-40 (IL-40) and Interleukin-41 (IL-41), in patients with sepsis and its more severe form,...
Detailed Description
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection and is evaluated by an increase of two or more points in the Sequential Organ Failure Asse...
Eligibility Criteria
Inclusion
- Patient Group:
- Clinical diagnosis of sepsis or septic shock, based on validated diagnostic criteria (e.g., Sepsis-3)
- Age 18 years or older
- Ability and willingness to provide a blood sample prior to initiation of antibiotic treatment
- Healthy Control Group:
- Determined to be in good general health based on physical examination and medical history
- Age 18 years or older
- Willingness to provide written informed consent
Exclusion
- Patient Group:
- History of chronic inflammatory diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus)
- Active cancer or current use of immunosuppressive therapy
- Pregnant or breastfeeding
- Presence of other serious conditions that may interfere with diagnosis or treatment (e.g., liver failure, chronic kidney disease)
- Healthy Control Group:
- Recent infection within the past month or use of antibiotics in the last 6 weeks
- History of chronic inflammatory diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus)
- Underwent surgery within the past 6 months
- Conditions that may affect blood parameters, such as recent blood donation or intense physical activity
- Pregnant or breastfeeding
Key Trial Info
Start Date :
May 15 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06963541
Start Date
May 15 2025
End Date
December 31 2025
Last Update
May 9 2025
Active Locations (1)
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1
Harran University Faculty of Medicine, Department of Anesthesiology and Reanimation
Sanliurfa, Turkey (Türkiye), 630000