Status:
COMPLETED
Physiological Dead Space and Intensive Care Mortality in Mechanically Ventilated Patients
Lead Sponsor:
Karadeniz Technical University
Conditions:
Invasive Mechanical Ventilation
Ventilation-Perfusion Mismatch
Eligibility:
All Genders
18+ years
Brief Summary
This study investigates the relationship between physiological dead space and clinical outcomes, specifically mortality and discharge status, in adult patients receiving invasive mechanical ventilatio...
Detailed Description
Physiological dead space is defined as the portion of tidal volume that does not participate in effective gas exchange. It includes both anatomical and alveolar components and is a dynamic marker infl...
Eligibility Criteria
Inclusion
- Admitted to the intensive care unit
- Receiving invasive mechanical ventilation
- Monitored with volumetric capnography and arterial blood gas analysis
- Informed consent obtained from legal representatives
Exclusion
- Patients under 18 years of age
- ICU length of stay less than 24 hours
- Patient or legal representative refused participation
- Hemoglobin level \< 7 g/dL
- Arterial PaCO₂ \> 70 mmHg
- Signs of circulatory failure
- Lactate \> 4 mmol/L
- Capillary refill time \> 3 seconds
- PaCO₂ - Central venous CO₂ gradient \> 8 mmHg (if applicable)
- Mean arterial pressure (MAP) \< 65 mmHg
- Mottling score ≥ 2
- Body temperature \> 38°C
- Arterial pH \< 7.20
- Body mass index (BMI) \> 40 kg/m²
- Carbon dioxide production (VCO₂) \> 4 mL/kg
Key Trial Info
Start Date :
January 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 19 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06963944
Start Date
January 1 2024
End Date
April 19 2025
Last Update
May 9 2025
Active Locations (1)
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1
Karadeniz Technical University
Trabzon, Turkey (Türkiye), 61080