Status:
NOT_YET_RECRUITING
Immediate Fracture Risk After Antihypertensive Drug Initiation
Lead Sponsor:
Ajou University School of Medicine
Conditions:
Hypertension
Fracture
Eligibility:
All Genders
50-100 years
Brief Summary
This retrospective observational study aims to evaluate the short-term fracture risk associated with anti-hypertensive medication initiation using a self-controlled case series (SCCS) design and inves...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Individuals with at least 365 days of continuous observation prior to the index date (defined as the date of first antihypertensive medication prescription), with no prior antihypertensive use during that period
- At least one diagnosis of hypertension (ICD-10 codes I10-I13, I15) recorded within 180 days before the index date
- Exclusion Criteria (main cohort):
- Any of the following occurring in the 365 days prior to the index date: Hospitalization (inpatient admission, including long-term care facility), transport-related trauma (ICD-10 codes V01-V99), Intentional self-harm (ICD-10 codes X60-X84, Y87), History of pathological fractures (e.g., M84.4, M90.7), Evidence of end-stage renal disease (ESRD), dialysis, kidney transplant, renal osteodystrophy
Exclusion
Key Trial Info
Start Date :
June 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 31 2025
Estimated Enrollment :
10000000 Patients enrolled
Trial Details
Trial ID
NCT06964217
Start Date
June 1 2025
End Date
July 31 2025
Last Update
May 28 2025
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