Status:
NOT_YET_RECRUITING
Awake Prone Positioning of Patients Suffering Community Acquired Pneumonia Requiring Nasal High Flow Therapy
Lead Sponsor:
University Hospital, Tours
Conditions:
Community-acquired Pneumonia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Community acquired pneumonia, in particular when requiring oxygen therapy because of acute hypoxemic respiratory failure and meeting acute respiratory distress syndrome (ARDS) criteria frequently lead...
Eligibility Criteria
Inclusion
- Adult patients admitted to an intensive care unit or intermediate care unit
- Suspicion of community acquired pneumonia (at least one of the 3 criteria): fever, cough, purulent expectoration
- And abnormalities suggestive of pneumonia by chest X-ray or CT-scan
- PaO2/FiO2 ratio \<300 mmHg (or equivalent SpO2/FiO2 i.e. \< 315 mmHg) under a minimum gas flow of 30 L/min.
- Person affiliated to a French social security system or equivalent
- Informed consent.
Exclusion
- Positive SARS-COV2 test within the last 30 days
- Indication for immediate intubation
- Patients for whom a "do not intubate" decision has been made
- Chest trauma or other contraindication to prone position
- Patients with formal indication for non-invasive ventilation: exacerbation of chronic obstructive pulmonary disease, acute cardiogenic pulmonary oedema.
- Pregnant or breastfeeding woman
- Subjects who are under legal protection measure
- More than 8h awake prone positioning prior to inclusion
- More than 48h since intensive care unit or intermediate care unit admission.
Key Trial Info
Start Date :
May 19 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2034
Estimated Enrollment :
1078 Patients enrolled
Trial Details
Trial ID
NCT06966310
Start Date
May 19 2025
End Date
April 1 2034
Last Update
May 11 2025
Active Locations (38)
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1
Intensive care, University Hospital, Amiens
Amiens, France
2
Intensive care, University Hospital, Angers
Angers, France
3
Intensive care, University Hospital, Argenteuil
Argenteuil, France
4
Intensive care, University Hospital, Belfort
Belfort, France