Status:
NOT_YET_RECRUITING
Accelerated vs Standard Approach to Continuous Veno-venous Hemodiafiltration Post-hemoperfusion (ASAP) in Severe Acute Diquat Poisoning
Lead Sponsor:
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Conditions:
Diquat Poisoning
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Diquat (1,1'-ethylene-2,2'-bipyridinium) is a bipyridine herbicide that shares a similar physicochemical structure and redox cycling mechanism with paraquat. Upon ingestion, it is rapidly absorbed and...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Age ≥ 18 years; and
- A history of oral exposure to diquat solution, reported by patient(s) or their legal proxies; and
- An exposure time (time form exposure to presentation at ED) ≤ 48 hours, reported by patient(s) or their legal proxies; and
- Plasma diquat concentration measured upon ED presentation ≥ 1,000 ng/mL.
- Exclusion criteria:
- Evidence of co-ingestion of other toxic substances alongside diquat; and/or
- Withholding of CVVHDF due to limitations on the escalation of life-sustaining therapies; and/or
- Any CKRT within the previous 2 months; and/or
- Kidney transplant within the past 365 days; and/or
- Known pre-hospitalization advanced chronic kidney disease, defined by an estimated glomerular filtration rate calculated using serum creatine (eGFRer) of less than 30 mL/min/1.73 m2 by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, if pre-hospitalization serum creatine is available; and/or (6) Treating clinician(s) believe(s) that either immediate or deferral of CVVHDF initiation is mandated; and/or (7) Pregnant or breast feeding.
Exclusion
Key Trial Info
Start Date :
January 1 2027
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2029
Estimated Enrollment :
267 Patients enrolled
Trial Details
Trial ID
NCT06966765
Start Date
January 1 2027
End Date
December 31 2029
Last Update
November 18 2025
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