Status:
NOT_YET_RECRUITING
Respiratory Stabilization in Chronic Acidosis Before Bronchofiberoscopy & Non-Invasive Ventilation Effectivenes
Lead Sponsor:
Medical University of Silesia
Conditions:
Chronic Respiratory Acidosis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Bronchofiberoscopy (FOB) is a minimally invasive and safe procedure performed for diagnostic and therapeutic purposes. FOB frequently impairs respiratory function, which may lead to possible exacerbat...
Detailed Description
Project description Assessment of the importance of respiratory stabilization in patients with chronic respiratory acidosis before undergoing bronchofiberoscopy for diagnostic purposes, as well as the...
Eligibility Criteria
Inclusion
- Patient ≥ 18 years of age with indications for diagnostic bronchoscopy:
- ◦ Diagnostic test: suspected lung cancer, suspected sarcoidosis, mediastinal lymphadenopathy,
- Patient who signed a written informed consent to participate in the study,
- pCO2 \> 45 mmHg and/or HCO3- \> 27 mmol/l but pH ≥ 7.35 in a blood gas test performed immediately before qualification for bronchoscopy.
Exclusion
- Lack of written informed consent of the subject to participate in the research project,
- Coronary artery disease CCS III/IV,
- Hemodynamic failure, use of pressor amines, myocardial infarction in the last 2 weeks without PCI treatment, unstable angina pectoris, severe arrhythmias - especially ventricular,
- Pneumothorax not secured with drainage,
- Platelet count \<20,000/µl, if platelets are not transfused immediately before/during the procedure,
- INR \> 1.5xULN or APTT \>36 s.1.5xULN, in the case of diagnostic FOB \[16\],
- Anemia: hemoglobin (Hb) level \<6 g/dl or 6-10 g/dl if the physician prescribes a blood transfu-sion,
- Patients who were intubated before randomization.
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 31 2028
Estimated Enrollment :
210 Patients enrolled
Trial Details
Trial ID
NCT06970002
Start Date
October 1 2025
End Date
October 31 2028
Last Update
May 14 2025
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