Status:

COMPLETED

Association of Vitamin D Status With Metabolic Markers in Adolescents With Polycystic Ovary Syndrome

Lead Sponsor:

Bagcilar Training and Research Hospital

Conditions:

Polycystic Ovary Syndrome

Vitamin D Deficiency

Eligibility:

FEMALE

13-19 years

Brief Summary

This prospective cross-sectional case-control study aims to investigate the relationship between serum vitamin D levels, visceral adipose tissue (VAT) thickness, and metabolic parameters in adolescent...

Detailed Description

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age, with manifestations often beginning during adolescence. It is associated not only with reproductive...

Eligibility Criteria

Inclusion

  • Female adolescents aged 13 to 19 years
  • Having attained menarche at least two years prior to enrollment
  • For PCOS group: Diagnosis of polycystic ovary syndrome based on NIH criteria (presence of menstrual irregularity and clinical and/or biochemical hyperandrogenism)
  • For Control group: Regular menstrual cycles (cycle interval 21-35 days) and no clinical or biochemical signs of hyperandrogenism.

Exclusion

  • Use of medications affecting vitamin D metabolism, insulin sensitivity, or androgen levels within the past 6 months (e.g., oral contraceptives, insulin sensitizers, vitamin D supplements)
  • Presence of endocrine disorders such as congenital adrenal hyperplasia, hyperprolactinemia, Cushing's syndrome, thyroid dysfunction.
  • Chronic systemic diseases (e.g., diabetes mellitus, severe liver or kidney disease).

Key Trial Info

Start Date :

March 1 2024

Trial Type :

OBSERVATIONAL

Allocation :

ACTUAL

End Date :

May 30 2025

Estimated Enrollment :

106 Patients enrolled

Trial Details

Trial ID

NCT06970821

Start Date

March 1 2024

End Date

May 30 2025

Last Update

September 18 2025

Active Locations (1)

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Bağcılar Training and Research Hospital

Istanbul, Turkey (Türkiye), 34200