Status:
NOT_YET_RECRUITING
Fermented Milk Drink With Lacticaseibacillus Paracasei Strain Shirota Helps Triathletes With Cold-Like Symptoms Before and After a Race
Lead Sponsor:
Federal University of São Paulo
Conditions:
Respiratory Tract Infections (RTI)
Mucosal Immunity
Eligibility:
All Genders
25-45 years
Phase:
NA
Brief Summary
This study aims to evaluate whether a fermented milk drink containing the probiotic strain Lacticaseibacillus paracasei strain Shirota (LCS), commonly found in Yakult®, can help reduce upper respirato...
Detailed Description
Background: Endurance athletes are frequently exposed to high physical stress, which may lead to temporary immune suppression and increased susceptibility to upper respiratory tract infections (URTIs...
Eligibility Criteria
Inclusion
- Aged between 25 and 45 years.
- Amateur triathletes with regular endurance training and prior competition experience.
- In good general health, with no history of chronic diseases or conditions affecting immune or inflammatory responses.
- Willing and able to comply with all study procedures, including sample collections and completion of validated questionnaires at five time points.
- Agree to consume a daily dose of fermented milk containing Lacticaseibacillus paracasei strain Shirota (LcS) or placebo from 30 days before until 14 days after the competition.
- No use of probiotics, antibiotics, or immunomodulatory supplements in the 30 days prior to enrollment
Exclusion
- Known allergy or intolerance to dairy products, including lactose.
- Use of probiotics or antibiotics within 30 days prior to enrollment.
- Current use of any pharmacological treatment.
- History of chronic rhinopathy.
- Diagnosis of autoimmune disease.
- History of recurrent infections not involving the upper airway.
- Presence of major medical conditions or chronic diseases, including but not limited to respiratory or gastrointestinal disorders.
- Incomplete or missing data necessary for determining eligibility or for study outcomes.
Key Trial Info
Start Date :
August 21 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 5 2025
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06970964
Start Date
August 21 2025
End Date
November 5 2025
Last Update
May 14 2025
Active Locations (1)
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1
Federal University of Sao Paulo
São Paulo, Brazil, 04039-032