Status:
RECRUITING
Accelerated iTBS for Depression: Monitoring Brain Hemodynamics With Simultaneous iTBS/fNIRS
Lead Sponsor:
The Hong Kong Polytechnic University
Conditions:
Depression
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
This study will investigate the cortical hemodynamic response variability of an accelerated form of TBS stimulation over left dorsolateral prefrontal cortex (DLPFC) using a concurrent TBS/fNIRS setup....
Eligibility Criteria
Inclusion
- aged 18 to 65;
- a clinical diagnosis of current nonpsychotic major depressive disorder by an experienced psychiatrist according to DSM-IV;
- no or stable (≥2 weeks) psychopharmacological medication;
- have not responded to at least one antidepressant medication;
- have not received any TMS treatment;
- and have a 17-item HAMD score ≥ 20.
Exclusion
- severe internal diseases;
- neurological disorders or a history of severe head injuries;
- having suicidal ideation;
- pregnancy;
- common MRI, fNIRS and TMS exclusion criteria, such as a history of brain surgery, head injury, cardiac pacemaker, deep brain stimulation, intracranial metallic particles, history of seizures
- antiepileptics and benzodiazepines corresponding to a dose of \>1 mg lorazepam/d.
Key Trial Info
Start Date :
March 19 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2025
Estimated Enrollment :
1 Patients enrolled
Trial Details
Trial ID
NCT06971549
Start Date
March 19 2025
End Date
June 30 2025
Last Update
May 14 2025
Active Locations (1)
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1
The Hong Kong Polytechnic University
Hong Kong, Hong Kong