Status:
RECRUITING
A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis
Lead Sponsor:
AbbVie
Conditions:
Rheumatoid Arthritis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will evaluate the efficacy and safety of targeted therapies through...
Eligibility Criteria
Inclusion
- At any time prior to the Screening Visit, participant must have been treated for \> or = 3 months with at least 1 b/tsDMARD therapy but continued to exhibit active RA, or had to discontinue due to intolerability or toxicity, irrespective of treatment duration. The maximum cap for prior use of b/tsDMARD is 2.
- Participant must be on a stable dose of methotrexate (MTX)
Exclusion
- Participant is taking nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen/paracetamol, low-potency opioids (tramadol, codeine, hydrocodone, alone or in combination with acetaminophen), oral corticosteroids (equivalent to ≤ 10 mg/day of prednisone), or inhaled corticosteroids for stable medical conditions unless they have been on stable doses for ≥ 1 week prior to Baseline Visit.
- History of any arthritis with onset prior to age 17 years or current diagnosis of inflammatory joint disease other than rheumatoid arthritis.
Key Trial Info
Start Date :
June 20 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2027
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT06972446
Start Date
June 20 2025
End Date
November 1 2027
Last Update
January 7 2026
Active Locations (44)
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1
Sun Valley Arthritis Center /ID# 278331
Peoria, Arizona, United States, 85381
2
Private Practice - Dr. David S. Hallegua /ID# 277608
Beverly Hills, California, United States, 90211
3
Advanced Clinical Research Center, LLC dba TriWest Research Associates /ID# 277826
Chula Vista, California, United States, 91910
4
Newport Huntington Medical Group /ID# 272439
Huntington Beach, California, United States, 92648-5994