Status:
RECRUITING
Post-Stroke Aphasia TMS
Lead Sponsor:
Medical College of Wisconsin
Conditions:
Aphasia
Stroke
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The investigator proposes to examine the effects of excitatory transcranial magnetic stimulation (TMS) combined with semantic feature analysis (SFA) language therapy to improve word-finding abilities ...
Detailed Description
In this project, the investigator will use functional neuroimaging and inhibitory TMS to determine precise therapy-responsive targets for excitatory TMS therapy with SFA. One group of stroke survivors...
Eligibility Criteria
Inclusion
- Diagnosed with left hemisphere stroke
- Consent date \>= 1 month after stroke onset
- Fluent in English
- 18 years of age or older
Exclusion
- Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing
- Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease)
- A chronic medical condition that is not treated or is unstable
- The presence of cardiac stimulators or pacemakers or intracardiac lines, neurostimulators, medication infusion device, any other implants near the scalp (e.g., cochlear implants) or in the eye, metal in the body (e.g., splinters, fragments, clips)
- Pregnancy
- History of skull fractures, or skin diseases
- History of ongoing or unmanaged seizures
- Presence of factors that potentially decrease seizure thresholds: on pro-convulsant medications, untreated sleep deprivation or insomnia, ongoing alcoholism or illegal drug abuse (e.g., cocaine or MDMA users)
- History of dyslexia or other developmental learning disabilities
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2036
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06974279
Start Date
September 1 2025
End Date
December 31 2036
Last Update
September 19 2025
Active Locations (1)
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1
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226