Status:
NOT_YET_RECRUITING
Study on the Mechanism of Multi-group Analysis of the Influence of Depression on Common Cardiovascular Diseases
Lead Sponsor:
First Affiliated Hospital of Harbin Medical University
Conditions:
Depression and CVD
Eligibility:
All Genders
Up to 85 years
Brief Summary
Cardiovascular disease is the main cause of death in the world, accounting for 32% of all deaths. In 2019, the number of people suffering from cardiovascular diseases in the world was about 523 millio...
Eligibility Criteria
Inclusion
- Healthy control group 1) Good health and no gastrointestinal diseases; 2) No previous history of mental illness; 3) No previous history of cardiovascular disease;
- Depression group
- 1\) Meet the diagnostic criteria of the latest guidelines for depression, and be clinically diagnosed by at least two psychiatrists; 2) Patients with first-episode depression; 3) Have not taken any psychoactive drugs before or have not taken any psychoactive drugs within 4 weeks.
- 3\. Depression with cardiovascular disease group
- Meet the diagnostic criteria of the latest guidelines for depression, and be clinically diagnosed by at least two psychiatrists;
- Patients with first-episode depression;
- Have not taken any psychoactive drugs before or have not taken any psychoactive drugs within 4 weeks.
- There is definite clinical evidence of heart failure, coronary heart disease, hypertension or arrhythmia.
Exclusion
- Have a history of alcohol dependence, organic brain diseases, nervous system diseases and other complex mental diseases;
- Long-term use of psychoactive drugs/use of psychoactive drugs within 4 weeks;
- Patients with thyroid dysfunction
- Patients with severe liver and kidney dysfunction;
- Patients with chronic obstructive pulmonary disease, interstitial pulmonary fibrosis and pulmonary hypertension;
- Patients with autoimmune diseases and tumors;
- used antibiotics, yogurt or other drugs or foods that affect intestinal flora within 4 weeks;
- Pregnant or lactating women;
- There is a serious impairment of cognitive function, which makes it impossible to cooperate with the research procedure;
- Have received invasive medical procedures such as gastroscopy and colonoscopy in the past three months;
- The diet has changed greatly in the past week;
- Participate in simultaneous clinical trials;
- Refuse to sign the informed consent for participating in the experiment.
Key Trial Info
Start Date :
May 25 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2029
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT06975592
Start Date
May 25 2025
End Date
July 1 2029
Last Update
May 16 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China, 150000