Status:
COMPLETED
Mechanical Ventilator Weaning in Chronically Ventilated Patients
Lead Sponsor:
University of California, Los Angeles
Collaborating Sponsors:
Barlow Respiratory Hospital
Conditions:
Mechanical Ventilation Complication
Eligibility:
All Genders
Phase:
NA
Brief Summary
Mechanical ventilation is a commonly used life-saving hospital procedure for patients with severe breathing difficulty. Some patients have difficulty separating from the ventilator and need to be remo...
Detailed Description
Study protocol: 1. Patients will be considered for enrollment in the study within 72 hours of admission to BRH. 2. All Barlow Respiratory Hospital (BRH) patients requiring positive pressure invasive ...
Eligibility Criteria
Inclusion
- Patients requiring positive pressure mechanical ventilation for at least 21 days prior to BRH admission and
- Have a secure tracheostomy.
Exclusion
- Inability to obtain informed consent from patient or DPOA
- Incarcerated patients
- Patients with less than 3 months of life expectancy
- Patients requiring vasopressor medication to stabilize blood pressure on admission
- Systolic blood pressure less than 90mmHg on admission
- Pulse less than 50 or greater than 130 beats per minute or change by more than 20 from baseline on admission
- Respiratory rate greater than 35/min
- Oxygen saturation less than 90%
- PEEP\>5cmH2O
- Lung tidal volume less than 250ml despite MV support
- At least one previous admission to BRH with unsuccessful ventilator liberation attempt
- Length of Stay (LOS) at BRH less than 24hours
- Patients pass spontaneous breathing trial (SBT) on D1 and eligible for cool aerosol, except if they fail SBT on D2 and require continued MV
Key Trial Info
Start Date :
September 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 29 2025
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT06976554
Start Date
September 1 2023
End Date
July 29 2025
Last Update
August 3 2025
Active Locations (1)
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1
Barlow Respiratory Hospital
Los Angeles, California, United States, 90026