Status:
RECRUITING
Physical Activity on Neuroinflammation in Parkinson's Disease
Lead Sponsor:
IRCCS National Neurological Institute "C. Mondino" Foundation
Conditions:
Parkinson Disease
Physical Inactivity
Eligibility:
All Genders
40-80 years
Brief Summary
Parkinson's Disease (PD) is a chronic progressive neurodegenerative disorder clinically defined by the association of resting tremor, rigidity, bradykinesia, and postural instability. The histopatholo...
Detailed Description
Parkinson's disease (PD) is a chronic, progressive neurodegenerative disorder clinically defined by the presence of resting tremor, rigidity, bradykinesia, and postural instability. Pathologically, PD...
Eligibility Criteria
Inclusion
- Subjects of both sexes, aged between 40 and 80 years (extremes included)
- Diagnosis of Parkinson's disease according to the clinical diagnostic criteria of the Movement Disorder Society
- Hoehn \& Yahr between 1 and 3
Exclusion
- Concomitant diagnosis of other neurological diseases
- Presence of confirmed cognitive decline (MMSE \< 24)
- Presence of depression with (BDI \> 40)
- Patients with deep brain stimulation implant or undergoing DuoDopa therapy
- Presence of significant diseases affecting the musculoskeletal system
- Presence of internal medicine conditions, considered clinically significant by the investigator
- Acute or recent infections
- Body Mass Index (BMI) \>= 30
- Active smoking behavior
- Ongoing treatment with N-acetylcysteine or anti-oxidants
- Pregnancy or lactation
Key Trial Info
Start Date :
January 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06977204
Start Date
January 1 2023
End Date
June 1 2026
Last Update
May 18 2025
Active Locations (1)
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1
IRCCS Mondino Foundation
Pavia, Pavia, Italy, 27100