Status:
NOT_YET_RECRUITING
The 'Bone-Brain' Crosstalk Mechanism of Subchondral Bone Nociceptive Sensitization Activating SPP1-Positive Microglia in the vlPAG Region Elucidates the Theoretical Connotation of Treating Knee Osteoarthritis Based on Kidney Differentiation
Lead Sponsor:
Jinchao Xu
Conditions:
Osteoarthitis
Eligibility:
All Genders
60-70 years
Brief Summary
The aim of this observational study is to investigate the relationship between pain severity and alterations in bone-derived and brain-derived signaling molecules (including serum neurotransmitters an...
Eligibility Criteria
Inclusion
- Clinical diagnosis of KOA
- Age between 60-70 years.
- Kellgren-Lawrence grade IV on anteroposterior and lateral knee X-rays.
- Scheduled for total knee arthroplasty.
- Voluntarily signs informed consent.
Exclusion
- Clinical diagnosis of ankylosing spondylitis, rheumatoid arthritis, gout, or other related conditions.
- Presence of metabolic bone diseases, acute trauma, malignancies, infections, or other complications severely affecting knee function.
- Use of drugs affecting bone metabolism (e.g., corticosteroids, zoledronic acid) within the past 6 months.
- Presence of psychiatric disorders or serious cardiovascular, pulmonary, renal, hepatic, hematologic, or other systemic diseases.
- Contraindications to MRI.
Key Trial Info
Start Date :
June 15 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2026
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06977282
Start Date
June 15 2025
End Date
December 30 2026
Last Update
May 18 2025
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