Status:
NOT_YET_RECRUITING
DIALOG: Understanding Disorganisation: A Language-focused Global Initiative in Psychosis
Lead Sponsor:
Douglas Mental Health University Institute
Conditions:
Psychosis
Schizophrenia Disorders
Eligibility:
All Genders
18-65 years
Brief Summary
Disorganized speech, language and communication, also called 'formal thought disorder,' is a key part of severe mental illnesses like psychosis and mood disorders. When someone's communication is diso...
Detailed Description
Disorganisation is a multidimensional, cross-diagnostic symptom in SMD, but its quality, persistence, and severity varies markedly across diagnoses. Current knowledge on the pathophysiology of disorga...
Eligibility Criteria
Inclusion
- \- English or French speaking participants, male or female; age 18-65 years. Patients who have been previously diagnosed by their treating physician based on the Diagnostic and Statistical Manual of Mental Disorders 5 Edition (DSM 5) criteria for schizophrenia or schizoaffective disorder. Ethnically and socioeconomically diverse individuals from urban catchments. Women are under-represented in psychosis studies but across sexes disorganisation is equally severe. We aim for \>40% women in our samples via broader inclusion criteria not limited to schizophrenia.
- Healthy Controls group-matched with the patients for age (within 2 years), and sex matched to patient sample; and have no personal or first-degree family history of Severe Mental Disorders (SMD).
Exclusion
- Pregnancy; substance-induced psychosis with no SMD; neurological speech or auditory impairment, contraindication for MRI; Not able to give informed consent (if this is in doubt at the time of referral, we will formally test it). Not be able to speak French or English for clinical interactions; participants who are not proficient will be excluded.
Key Trial Info
Start Date :
May 19 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 30 2030
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06978465
Start Date
May 19 2025
End Date
April 30 2030
Last Update
May 18 2025
Active Locations (1)
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1
Douglas Mental Health University Institute
Montreal, Quebec, Canada, H4H1R3